Lessons from the Liver

The client: Dr Nicholas Hannan 

The brief: To create a series of 5 figures for the journal review Disease modeling using human induced pluripotent stem cells. The figures were to show how a stem cell gives rise to indefinitely more cells of the same type, and differentiates to produce certain other kinds of cell (in this case, hepatocytes); to detail at what stage embryonic stem cells are harvested; to explain stages of embryogenesis and at what stage gut tissue is developed; to show the levels of different factors present in the gut during embryo development and how this affects the differentiation of gut tissues; and to detail the potential applications induced pluripotent stem cells in creating patient-specific medicines. 


Figure 3: Embryogenesis, detailing the development of endoderm and it giving rise to lungs, liver and pancreas. 

Figure 2: Embryonic development, detailing the blastocyst stage, at which embryonic stem cells would be harvested. 

Figure 5: Using the patient's own skin cells, reprogrammed to develop patient-specific medicines, or transplanting fresh tissue to the patient with no rejection

Figure 4: Showing concentrations of FGF, BMP and RA during gut development 

Figure 1: A pluripotent stem cell giving rise to more of its stem cell line, and creating differentiated hepatocyte (liver) cells


The outcome: the client favoured a clean, yet traditional look for the final figures. Watercolour was used to identify key features in the figures, and biro was used to highlight detail. The figures were published in a 2014 edition of the journal BBA Molecular and Cell Biology of Lipids.